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Indra Mani Sharma

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Articles

The integrated stress response regulates 18S nonfunctional rRNA decay in mammals

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By Aaztli R Coria, Akruti Shah, Mohammad Shafieinouri, Sarah Taylor, Emilien Orgebin, Wilfried M. Guiblet, JENNIFER MILLER, Indra Mani Sharma, Colin Chih-Chien Wu
| Cell Press Verified
Keywords nonfunctional 18S rRNA integrated stress response ribosome stalling GCN2 RIOK3 Introduction The ribosome is central to controlling gene expression and translating genomic information into functional proteins. This process is governed by the decoding center of the small ribosomal subunit and the peptidyl transferase center of the large ribosomal subunit.1 In Saccharomyces cerevisiae (S.
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