Ingrid Yao Mattisson

Open AccessArticle by 1, 2, 3, 1, 1,4,5,*, 1, 1, 6 and 1,7 1 Department of Clinical Sciences, Lund University, 214 28 Malmö, Sweden 2 Department of Internal Medicine, Skåne University Hospital, 214 28 Malmö, Sweden 3 Department of Cardiology, Skåne University Hospital, 214 28 Malmö, Sweden 4 Department of Neuroscience, Imaging and Clinical Sciences, “G.d’Annunzio” University of Chieti-Pescara, Via dei Vestini 33, 66100 Chieti, Italy 5 Fondazione Villa Serena per la Ricerca, 65013 Città...

3.1. Method Validation and Analytical Quality Control 3.1.1. Limits of Detection and Quantification The limit of detection (LOD) is defined as the lowest concentration of analyte in a sample, which can be detected, though not necessarily quantified. Blank samples (in 15.2% HNO3 + 5.3% H2O2) were run at least six times. The LOD is calculated according to: where σ is the standard deviation of the response and S is the slope of the calibration curve.