Institut André Lwoff on Muck Rack

Institut André Lwoff

As seen in: The Journal of Biological Chemistry
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Articles

New insights into the tetraspanin Tspan5 using novel monoclonal antibodies

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By Julien Saint-Pol, Martine Billard, Emmanuel Dornier, Institut André Lwoff
| The Journal of Biological Chemistry Verified
Tspan5 is a member of a subgroup of tetraspanins referred to as TspanC8. These tetraspanins directly interact with the metalloprotease ADAM10, regulate its exit from the endoplasmic reticulum and subsequent trafficking, and differentially regulate its ability to cleave various substrates and activate Notch signaling. The study of Tspan5 has been limited by the lack of good antibodies.
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