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Iris Barshack on Muck Rack

Iris Barshack

As seen in: Nature, Archives of Pathology, Lung Cancer
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Articles

Prediction of OncotypeDX recurrence score using hematoxylin and eosin-stained whole slide images

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By Shachar Ben Cohen, Gil Shamai, Edmond Sabo, Alexandra Cretu, Iris Barshack, Gil Bar-Sela, Alexander Pearson, Dezheng Huo, Frederick Howard, Ron Kimmel, Chen Mayer, Tal Goldman
| Nature Verified
Abstract The OncotypeDX 21-gene assay guides adjuvant chemotherapy decisions in early-stage, hormone receptor–positive, HER2-negative breast cancer, but cost and turnaround time limit access. This study presents a deep learning-based approach for predicting OncotypeDX recurrence scores directly from hematoxylin and eosin-stained whole slide images. Our approach leverages a deep learning foundation model pre-trained on 171,189 slides via self-supervised learning, which is fine-tuned for our task.
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