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Isaac A. Babarinde on Muck Rack

Isaac A. Babarinde

As seen in: Nature, BioRxiv, Cell Reports
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Articles

Dissecting the Contribution of Transposable Elements to Interphase Chromosome Structure

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By Liyang Shi, Xiao juan Zhen, Isaac A. Babarinde, Xiuling Fu
| BioRxiv
Abstract Transposable elements (TEs) occupy nearly half of the human genome and play diverse biological roles. Despite their abundance, the extent to which TEs contribute to three-dimensional (3D) genome structure remains unclear. To investigate this, we developed te_hic, a computational pipeline that integrates genomic data with chromatin interactions. Our analysis reveals that TE sequences are responsible for 3D genome structure in interphase nuclei.
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Transposable Element Expression and Sub-cellular Dynamics During hPSC Differentiation to Endoderm, Mesoderm, and Ectoderm Lineages

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By Isaac A. Babarinde, Xiuling Fu, Gang Ma, Yuhao Li
| BioRxiv
Abstract Transposable elements (TEs) are genomic elements that are found in multiple copies in mammalian genomes. TEs were previously thought to have little functional relevance but recent studies have reported TE roles in multiple biological processes, particularly in embryonic development.
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The effects of sequencing depth on the assembly of coding and noncoding transcripts in the human genome

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By Isaac A. Babarinde, Andrew Hutchins
| BioRxiv
New Results Isaac A Babarinde, View ORCID ProfileAndrew P Hutchins doi: https://doi.org/10.1101/2022.01.30.478357 Abstract Background: Investigating the functions and activities of genes requires proper annotation of the transcribed units. However, transcript assembly efforts have produced a surprisingly large variation in the number of transcripts, and especially so for noncoding transcripts. The heterogeneity of the assembled transcript sets might be partially explained by sequencing depth.
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