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Isabel Ribeiro Bravo on Muck Rack

Isabel Ribeiro Bravo

As seen in: BioRxiv, Cell Press
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Articles

Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response

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By Abigail M Elliot, Isabel Ribeiro Bravo, Jeanette Astorga Johansson, Esme Hutton
| BioRxiv
Abstract Oncogenic driver mutations are frequently found in normal tissues, suggesting that additional non-genetic factors are required for tumourigenesis. Phenotypic plasticity is an important gateway to malignancy and inflammation can fuel tumourigenesis, however, little is known about when and how these hallmarks first arise.
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Oncogenic RAS drives rapid onset cellular plasticity and elicits a tumour-promoting neutrophil response at the inception of preneoplastic development

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By Abigail M Elliot, Isabel Ribeiro Bravo, Jeanette Astorga Johansson, Esme Hutton
| BioRxiv
Abstract To date, very little is known regarding the earliest cellular and molecular events within the initial preneoplastic cell (PNC) niche that might determine the outcome of PNC development. Here, we combine in vivo live imaging and single cell transcriptomics to investigate the immediate cellular and molecular changes that occur in PNCs and responding innate immune cells within the first 24 hours following tumour initiation.
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Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation

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By Deborah Carter Verified, Lucy MacCarthy-Morrogh, Josephine Morris, Isabel Ribeiro Bravo
| Cell Press Verified
Highlights • Macrophages and neutrophils breach the basement membrane zone to access cancer cells • Breaching is by proteolysis or opportunistically through pre-existing weak spots • Clones near BMZ weak spots gain a growth advantage from immune cell infiltration • Wounds provide another portal for immune cells to gain access to the epithelium Summary Cancer-related inflammation impacts significantly on cancer development and progression.
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