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Isabel Sousa Barata on Muck Rack

Isabel Sousa Barata

As seen in: BioRxiv
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Articles

Curcumin and Piperine Nanoparticles inhibit CYP17A1 activity to Regulate Steroid Biosynthesis in Prostate Cancer

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By Jibira Yakubu, Therina du Toit, Isabel Sousa Barata, Oya Tagit
| Preprints.org
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 24 October 2024 / Approved: 25 October 2024 / Online: 28 October 2024 (13:27:16 CET) Yakubu, J.; natsaridis, E.; du Toit, T.; Sousa Barata, I.; Tagit, O.; Pandey, A. Curcumin and Piperine Nanoparticles inhibit CYP17A1 activity to Regulate Steroid Biosynthesis in Prostate Cancer. Preprints 2024, 2024102072.
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Nanoparticles with Curcumin and Piperine Modulate Steroid Biosynthesis in Prostate Cancer

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By Jibira Yakubu, Evangelos Natsaridis, Therina du Toit, Isabel Sousa Barata
| BioRxiv
Abstract Endogenous androgens are pivotal in the development and progression of prostate cancer (PC). We investigated nanoparticle formulations of curcumin and piperine in modulating steroidogenesis within PC cells. Using multiple PC cell lines (LNCaP, VCaP, DU145 and PC3) we studied the effects of curcumin, piperine, and their nanoparticle formulations, curcumin nanoparticles, piperine nanoparticles, and curcumin-piperine nanoparticles (CPN) on cell viability, migration, and steroid biosynthesis.
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