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Isabell Behrens

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Articles

Extracellular traps from myeloid cells as therapeutic targets in traumatic heterotopic ossification

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By David R. Ziehr, PING LIU, Shan Jiang, Holger Kleinertz, Weixin Xie, Elena Müller, Simon von Kroge, Assil-Ramin Alimy, Milad Farkhondeh Fal, Michael Amling, Eva Tolosa, Thomas Renné, Karl-Heinz Frosch, Konrad Mader, Tim Rolvien, Anke Baranowsky, Alka Khaitan, Gesine Eis-Janzyk, Ruben Augustin, Saskia Schröder, Jan Sevecke, Haoyan Pan, Isabell Behrens, Samira Weisselberg, Lilly-Charlotte Albertsen
| Science Magazine Verified
Editor’s summary Musculoskeletal injuries, including tendon and ligament trauma, can lead to ectopic bone formation near the site of injury, and there are few effective treatments available to prevent this traumatic heterotopic ossification (HO). Here, Jiang et al. found that myeloid cells deposit extracellular traps (ETs) at sites of HO in humans and mice. Using genetic loss-of-function and gain-of-function studies in mice, the authors show that ETs are associated with HO severity.
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