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ISGs Are Downregulated

As seen in: Cell Press
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Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics

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By Dylan Kotliar, Aaron E. Lin, Bystander Monocytes, ISGs Are Downregulated
| Cell Press Verified
Highlights • Interferon response is suppressed in infected cells but activated in bystander cells • EBOV represses antiviral genes and upregulates pro-viral genes in infected cells • Proliferative CD14– CD16– monocyte precursors expand in circulation during EVD • Identification of expression markers of EBOV tropism for circulating cells in vivo Summary Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to the challenge of experimentation in high-containment...
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