Ishika Pramanick on Muck Rack

Ishika Pramanick

As seen in: Cell Press
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Articles

Conformational flexibility and structural variability of SARS-CoV2 S protein

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By Nayanika Sengupta, Suman Devi Mishra, Suman Pandey, Ishika Pramanick
| Cell Press Verified
Highlights • Structural flexibility and variability of S protein at (near) physiological pH • Predominance of 1-RBD up conformation at pH 7.4 • Differential surface exposure of amino acid residues that bind neutralizing antibody • Diverse length and orientation of stalk domain of S2 subunit Summary Spike (S) glycoprotein of SARS-CoV2 exists chiefly in two conformations, open and closed.
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