Iskra Pollak Dorocic on Muck Rack

Iskra Pollak Dorocic

As seen in: Nature, Cell Press
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Articles

Effects of SSRIs on the spatial transcriptome of dorsal raphe serotonin neurons

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By Charlotta Henningson, Jakub Mlost, Iskra Pollak Dorocic
| Nature Verified
Abstract The serotonin system is the main therapeutic target for selective serotonin reuptake inhibitors (SSRIs) in treating depression, yet the mechanism of action of SSRIs remains incompletely understood. To investigate the molecular and transcriptional effects of SSRI administration on serotonin neurons, we performed spatial transcriptomics, a spatially resolved RNA-sequencing method in intact brain tissue.
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Effects of SSRIs on the spatial transcriptome of dorsal raphe serotonin neurons

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By Jakub Mlost, Iskra Pollak Dorocic, Charlotta Henningson
| biorxiv.org
Abstract The serotonin system is the main therapeutic target for selective serotonin reuptake inhibitors (SSRIs) in treating depression, yet their mechanism of action remains incompletely understood. To investigate the molecular and transcriptional effects of SSRI administration on serotonin neurons, we performed spatial transcriptomics, a spatially resolved RNA sequencing method in intact brain tissue.
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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

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By Seyedeh Atiyeh Afjei, Iskra Pollak Dorocic, James Peck, Christine Liu
| Cell Press Verified
References Abercrombie E.D. Keefe K.A. DiFrischia D.S. Zigmond M.J. Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex. J. Neurochem. 1989; 52: 1655-1658 Badrinarayan A. Wescott S.A. Vander Weele C.M. Saunders B.T. Couturier B.E. Maren S. Aragona B.J. Aversive stimuli differentially modulate real-time dopamine transmission dynamics within the nucleus accumbens core and shell. J. Neurosci. 2012; 32: 15779-15790 Bassareo V.
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