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Ivan Merelli

As seen in: Nature, Science Magazine, Cell Reports, Cell Reports Medicine, Cell Stem Cell
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Articles by Ivan Merelli

Oncogenic signalling and host immunocompetency govern senescent cell clearance and systemic inflammation in a mouse model of oncogene-induced senescence

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By Pierangela Gallina, Laura Rudilosso, Fabrizio Benedicenti, Martina Rocchi, Rossana Norata, Sara Degl’Innocenti, Tommaso Sconocchia, Kety Giannetti, Dimitri Bulté, Anna Villa, Alessandra Mortellaro, Raffaella Di Micco, Ivan Merelli, Francesca Sanvito, Daniela Cesana, Eugenio Montini, Cristina Colleoni, Leonardo Ormoli
| Nature Verified
Abstract Senescence is a stress-induced program defined by permanent cell-cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP). Defective clearance of senescent cells promotes inflammation, tissue dysfunction, and ageing, yet determinants of their elimination remain poorly understood.
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Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity

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By Diego Gilioli, Simona Fusco, Teresa Tavella, Tatiana Volpari, Antonella Santoro, Martin Schönlein, Kety Giannetti, Edoardo Carsana, Nicolò Gualandi, Roberta Noberini, Chiara Brombin, Salvatore Russo, Sara Feola, Yvonne Giannoula, Janne Lehtiö, Tiina Sikanen, Markus Haapala, Laura Passerini, Giacomo Farina, Anastasia Conti, Lucrezia della Volpe, Matteo Barcella, Stefano Beretta, Federico Aletti, Matteo Giovanni Carrabba, Silvia Gregori, Chiara Bonini, Ivan Merelli, Fabio Ciceri, Vincenzo Cerullo, Tiziana Bonaldi, Luca Vago, Clemens A. Schmitt, Raffaella Di Micco, Rui M. M. Branca, Angela Andrisani, Alessia Zangari
| Nature Verified
Abstract Chemotherapy resistance and disease relapse are major determinants of treatment failure in acute myeloid leukemia (AML). Therapy-induced senescence (TIS) is one outcome of chemotherapy, but its immunological consequences in AML remain unclear. Here we show that ex vivo chemotherapy induces senescence in a subset of therapy-naïve AML samples.
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Nanoengineered 3D culture substrate enables superior persistence and polyclonal engraftment of genetically engineered hematopoietic stem cells

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By Federico Midena, Laura Alessandrini, Matteo Barcella, Francesco Gazzo, Emanuela Jacchetti, Edoardo Carsana, Roberta Vacca, Lucrezia della Volpe, Sergio Arévalo, Kety Giannetti, Erika Zonari, Francesca Ferrua, Giacomo Farina, Chiara Brombin, Federica Cugnata, Martina Fiumara, Teresa Tavella, Giulio Cerullo, Roberto Osellame, Samuele Ferrari, Ivan Merelli, Bernhard Gentner, Luigi Naldini, Alessandro Aiuti, Eugenio Montini, Raffaella Di Micco, Claudio Conci, Fabrizio Benedicenti, Dafne Barozzi, Martina Franchino, Leonardo Cherubin, Federico Fraschetta, Marina Radrizzani, Cristina Scielzo, Andrea Brendolan, Manuela T. Raimondi
| Cell Stem Cell Verified
STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Anti-8-oxo-2’deoxyguanosine Trevigen Cat#4354-MC-050; RRID: AB_1857195 Anti-alpha Tubulin antibody – Loading Control Abcam Cat#ab4074; RRID: AB_2288001 Anti-human CD11b PE (Clone M1/70) BioLegend Cat#101207; RRID: AB_312790 Anti-human CD13 BV421 (Clone WM15) BD Biosciences Cat#562596; RRID: AB_2737672 Anti-human CD133/1 PE-Vio 770 (Clone AC133) Miltenyi Biotec Cat#130-113-110; RRID: AB_2725939 Anti-human CD14 APC-Cy7 (Clone M5E2)...
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Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells

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By Anastasia Conti, Kety Giannetti, Federico Midena, Stefano Beretta, Nicolò Gualandi, Rosaria De Marco, Edoardo Carsana, Angelica Varesi, Teresa Tavella, Laura Alessandrini, Parinaz Zarghamian, Alessandra Weber, Samuele Ferrari, Chiara Brombin, Diego Gilioli, Lucrezia della Volpe, Stephanie Xie, Ivan Merelli, Toni Cathomen, Luigi Naldini, Raffaella Di Micco
| Cell Reports Medicine Verified
Keywords gene editing hematopoietic stem cells senescence DNA damage p53 inflammatory programs CRISPR-Cas9 viral vectors gene therapy genome integrity Introduction Gene editing (GE) in hematopoietic stem and progenitor cells (HSPCs) represents a transformative gene therapy approach for immune hematological and metabolic inherited human diseases.1,2,3,4 GE platforms, such as the CRISPR-Cas9 system, target DNA double-strand breaks (DSBs) for site-specific gene disruption or homology-mediated...
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Identification of hepatocyte-primed cholangiocytes in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates

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By Michela Milani, Anna Fabiano, Stefano Beretta, Cesare Canepari, Mauro Biffi, Fabio Russo, Francesca Sanvito, Ivan Merelli, Meritxell Huch, Luigi Naldini, Alessio Cantore, Francesco Starinieri, Tiziana Plati, Valeria Berno, Rossana Norata, Luigi Aloia
| Cell Reports Verified
Keywords liver stem cells in vivo gene therapy lentiviral vectors liver organoids translational research large animal models liver damage Research topic(s) CP: Stem cell research Introduction The liver has an extensive regenerative capacity, as testified by its ability to regenerate following partial hepatectomy and reconstruct an entire liver after transplantation of a small portion.1 Despite being fully differentiated cells, hepatocytes maintain self-renewal capacity and the potential to...
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A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells

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By Teresa Tavella, Giacomo Farina, Chiara Brandas, Matteo M. Naldini, Matteo Barcella, Samuele Ferrari, Stefano Beretta, Antonella Santoro, Simona Porcellini, Angelica Varesi, Anastasia Conti, Ivan Merelli, Bernhard Gentner, Anna Villa, Luigi Naldini, Raffaella Di Micco, Lucrezia della Volpe, Federico Midena, Roberta Vacca, Laura Alessandrini, Elena Lo Furno, Kety Giannetti, Edoardo Carsana, Diego Gilioli
| Cell Reports Medicine Verified
Keywords hematopoietic stem cells p38 MAPK-ROS gene editing CRISPR-Cas9 DNA damage DNA damage response proliferative stress cell cycle differentiation single-cell analyses clonal output Introduction Ex vivo hematopoietic stem and progenitor cell (HSPC)-based gene therapies (GTs) represent a revolutionary class of “living medicines” for treating various monogenic diseases, including immunodeficiencies, hereditary anemias, and metabolic disorders.1,2 GT is a multi-step process encompassing the...
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