Iyad Ba Gari

Abstract Normative models of brain metrics based on large populations could be extremely valuable for detecting brain abnormalities in patients with a variety of disorders, including degenerative, psychiatric and neurodevelopmental conditions, but no such models exist for the brain’s white matter (WM) microstructure.

Abstract The corpus callosum (CC) is the largest set of white matter fibers connecting the two hemispheres of the brain. In humans, it is essential for coordinating sensorimotor responses and performing associative or executive functions. Identifying which genetic variants underpin CC morphometry can provide molecular insights into the CC’s role in mediating cognitive processes.

Samples and participants UK Biobank (UKB) is a UK population study of ~500,000 participants aged 40–69 years at recruitment66. Participant data include genomic, imaging data, electronic health record linkage, biomarkers, physical and anthropometric measurements. Further details are available at https://biobank.ndph.ox.ac.uk/showcase/. Informed consent was obtained from all participants. Analyses in this study were conducted under UK Biobank Approved Project numbers 26041 and 11559.