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J. Wesley Pike on Muck Rack

J. Wesley Pike

As seen in: The Journal of Biological Chemistry
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Articles

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By Lu Wang Verified, Mark Meyer, Wei Huang, Weibo Cai, Paul Ahlquist, Wei Xu, Zibo Zhao, Sandeep Saha, Menggang Yu, Ailan Guo, Kari B. Wisinski, J. Wesley Pike, Ming Yuan
| secure.jbs.elsevierhealth.com
Open in Who Shared Issue with article?

Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-Derived Mesenchymal Stem Cells

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By Mark Meyer, J. Wesley Pike, Nancy A. Benkusky, Buer Sen, Janet Rubin
| The Journal of Biological Chemistry Verified
Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade of activated transcription factors and epigenetic modifications that drive gene transcription responsible for unique cell fate. Within the mesenchymal lineage, factors such as RUNX2 and PPARγ are indispensable for osteogenesis and adipogenesis, respectively.
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