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Articles by J. William Harbour
Cytopathology and Prognostic Accuracy of 15-GEP/PRAME : The Collaborative Ocular Oncology Group Study 2
Cytopathology and Prognostic Accuracy of 15-GEP/PRAME: The Collaborative Ocular Oncology Group Study 2 Key Points Question Is confirmatory cytopathology associated with the prognostic accuracy of a 15-gene expression profile (15-GEP)/Preferentially Expressed Antigen in Melanoma (PRAME) classifier in predicting metastatic uveal melanoma risk?
Correction: Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis - Oncogene
Correction to: Oncogene (2023) 42:2629–2640 https://doi.org/10.1038/s41388-023-02792-6, published online 27 July 2023 Following the publication of this article, the authors noticed that Supplementary Table 1 contained an error. The source of the OMM1 uveal melanoma cell line was from a subcutis metastasis, rather than a liver metastasis as indicated in the original table. The authors confirm that this correction does not affect the study’s conclusions. The Supplementary material has been corrected.
Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis - Oncogene
Author notes Jackson R. Richards Present address: Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA These authors contributed equally: Shannon J. Odelberg, Jae Hyuk Yoo. Authors and Affiliations Department of Oncological Sciences, School of Medicine, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT, 84112, USA Jackson R.
Iris Mass in a 14-Month-Old Boy
A 14-month-old boy presented with a sudden-onset, rapidly enlarging lesion in the right eye detected by his parents 2 weeks earlier. The patient had normal tracking bilaterally. Under anesthesia, findings from an examination of the right eye revealed an inferonasal translucent gray-white iris mass with numerous intralesional lacy cystic structures (Figure 1). There was no microphthalmia, cataract, lens subluxation, anterior or posterior synechiae, glaucoma, or uveitis.
A novel cardiomyogenic role for Isl1+ neural crest cells in the inflow tract
Abstract The degree to which populations of cardiac progenitors (CPCs) persist in the postnatal heart remains a controversial issue in cardiobiology. To address this question, we conducted a spatiotemporally resolved analysis of CPC deployment dynamics, tracking cells expressing the pan-CPC gene Isl1.
Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer
Review Michele Carbone, J. William Harbour, James Brugarolas, Angela Bononi, Ian Pagano, Anwesha Dey, Thomas Krausz, Harvey I. Pass, Haining Yang and Giovanni Gaudino DOI: 10.1158/2159-8290.CD-19-1220 Published August 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
Single-cell analysis reveals new evolutionary complexity in uveal melanoma
Abstract Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Here, we interrogate the tumor microenvironment at single-cell resolution using scRNA-seq of 59,915 tumor and non-neoplastic cells from 8 primary and 3 metastatic samples. Tumor cells reveal novel subclonal genomic complexity and transcriptional states.
Anterior Chamber Chemotherapy in Retinoblastoma-Necessary But Not Sufficient for Aqueous Seeding Control-Reply
In Reply We appreciate the interest in our Observation and the opportunity to answer these thoughtful questions. First, we used intravitreal melphalan to treat the ciliary body tumor, whereas we used intracameral topotecan to treat the anterior chamber seeds.
Clinicopathologic Prognostic Factors and Survival in Uveal Melanoma
Importance Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis. Objective To determine whether any clinicopathologic factors provide independent prognostic information that may enhance the accuracy of the GEP classification.
Liquid Biopsy in Retinoblastoma
The management of advanced intraocular retinoblastoma is evolving rapidly, with enucleation progressively being supplanted by globe-sparing treatments, such as intra-arterial chemotherapy.1 While the battle to save more eyes is admirable, the judicious use of these new treatments is essential to avoid compromising the high survival rates that have been achieved in the United States and other developed countries.2 Retinoblastoma cell invasion of the optic nerve and choroid—2 of the most...
Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes
Importance Frequent mutations have been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B1. Understanding the prognostic significance of these mutations could facilitate their use in precision medicine. Objective To determine the associations between driver mutations, gene expression profile (GEP) classification, clinicopathologic features, and patient outcomes in UM.
Incorporating Clinical, Histological, and Genetic Parameters for Choroidal Melanoma Prognostication–Reply
In Reply I appreciate the opportunity to reply to opinions expressed by Coupland and colleagues regarding our recent article1 in which we showed that gene expression profile (GEP) class 2 uveal melanomas (UMs) have a better prognosis when their largest basal diameter (LBD) is smaller than 12 mm. Contrary to their assertion, we did not “advocate combining these 2 predictors,” because the prognostic contribution of LBD was negligible (approximately 10-fold less) compared with GEP.
Prognostic Implications of the Largest Basal Tumor Diameter vs the TNM Staging System in Association With the Gene Expression Profile for Uveal Melanoma—Reply
In Reply I appreciate the opportunity to respond to a letter from Kivelä and Finger regarding our recent article.1 This article confirmed prior reports showing that the prognostic accuracy of gene expression profiling (GEP) is superior to that of anatomic features used by the TNM staging system for uveal melanoma,2,3 and it showed that class 2 uveal melanomas were less likely to metastasize when their largest basal tumor diameter was less than 12 mm.
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