James Brugarolas on Muck Rack

James Brugarolas

Dallas
As seen in: Nature, Wiley Online Library, MDPI, Cell Press, Cell Reports Medicine, HemOnc Today, The Journal of Clinical Investigation, Cancer Discovery, European Urology, Archives of Pathology
Director Kidney Cancer Program at UT Southwestern Medical Center. Views my own/ RT not endorsements.
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Articles

HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer

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By Yong Wang, Yan Xiong, Shuiqiao Liu, Lei Bao, Xing Ping Qiu, Xiangyang Song, Vanina Toffessi Tcheuyap, Sipeng Wu, Mingyi Chen, James Brugarolas, Jian Jin, Yingfei Wang, Weibo Luo, Ilia Korboukh
| Cell Reports Medicine
Keywords HIF VHL DNMT TRAIL death receptors epigenetic vulnerability cell death priming Introduction Clear cell renal cell carcinoma (ccRCC), comprising ∼80% of kidney cancer cases, is characterized by VHL (von Hippel-Lindau) tumor suppressor gene loss.1 VHL specifically recognizes prolyl-hydroxylated proteins including the transcription factor hypoxia-inducible factor (HIF) α subunits and acts as an E3 ubiquitin ligase mediating degradation of these substrates at the 26S proteasome.2,3,4 As...
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Targeting HIF‐2α in renal cell carcinoma: Expanding upon belzutifan

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By Melanie Rodriguez, Qian Qin, Uttam K. Tambar, James Brugarolas
| Wiley Online Library
Qian Qin MD Department of Internal Medicine, Division of Hematology-Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA Contribution: Conceptualization, Writing - original draft, Writing - review & editing Search for more papers by this author
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Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis - Nature

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By Dylan Calhoon, Divya Bezwada, Feng Cai, Renfei Wu, Bailey Brooks, Gary Siuzdak, James Brugarolas, Derek Pratt, Ryan Weiss, Ralph J. DeBerardinis, Kıvanç Birsoy, Vanina Toffessi-Tcheuyap
| Nature
Abstract Lipids are essential components of cancer cells due to their structural and signalling roles1. To meet metabolic demands, many cancers take up extracellular lipids2,3,4,5; however, how these lipids contribute to cancer growth and progression remains poorly understood. Here, using functional genetic screens, we identify uptake of lipoproteins—the primary mechanism for lipid transport in circulation—as a key determinant of ferroptosis sensitivity in cancer.
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