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Articles

Rapid activation of ARF6 after RAF inhibition augments BRAF V600E and promotes therapy resistance

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By Junhua Wang, Yinshen Wee, Thomas Jacob, Aaron Rogers, Deja M. Brooks, Prachi Gupta, Emily Wilson Verified, tong liu, Eric Smith, michael davies, Martin McMahon, martin mcmahon, Sheri Holmen, Robert L. Judson-Torres, Roger Wolff, Allie H. Grossmann, Lise. K. Sorensen, Joshua K. H. Tay, YN Vashisht Gopal
| Nature Verified
Abstract The intrinsic ability of cancer cells to evade death underpins tumorigenesis, progression, metastasis, and the survival of drug-tolerant persister (DTP) cells. Herein, we discovered that the small GTPase ARF6 plays a central role in tumor survival by fortifying RAF oncoprotein levels. ARF6 activation was sufficient to increase BRAFV600E, ARAF, and CRAF proteins through a post-transcriptional mechanism, while sustained inhibition of ARF6 eventually led to decay.
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Comment: This is Canada’s moment, so let’s seize it

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By Martin McMahon, martin mcmahon
| Times Colonist Verified
A commentary by a retired business professor. He lives in Oak Bay. History can be a bit like geology, where tectonic plates awaken from decades of slumber and tranquility, only to shift, bringing destruction and permanently altering geography. We are on the cusp of a plate shift that will radically reshape the global order and Canada’s place in it. Since the end of the Second World War, we experienced a period of relative peace.
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Comment: Canadian negotiators might have already given up leverage

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By Martin McMahon, martin mcmahon
| Times Colonist Verified
A commentary by a retired business professor who taught negotiations. He lives in Oak Bay. Witness U.S. President Donald Trump’s approach to tariffs, and you have all the insight you need to understand his philosophy when it comes to negotiations. He doesn’t approach negotiations from a traditional “win, win” perspective. His goal is to crush you.
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