Jaap-Jan Roukens

Figure 6 was corrected to match the data provided in the Supporting Information by removing data for a cpd (R,R)-64, which does not appear in the publication. Figure 6 Figure 6. Preliminary structure–activity relationship (SAR) data of halogenated analogues of (R,R)-1a. Bar plot showing the comparative inhibitory activity on monoamine transporters NET, DAT, and SERT. Data are shown as mean of two measurements each performed in triplicates.

This version is not peer-reviewed. You are already at the latest version Hidradenitis suppurativa (HS) is a severe inflammatory dermatosis characterized by profound localized pain. While current pathophysiological feedback loops (vicious cycles) focus on microscopic molecular networks and microbiological dysbiosis, the psychosocial and behavioral burdens of HS are individually well-documented. However, these behavioral maladaptations have not been integrated into a unified macroscopic model.

This version is not peer-reviewed. Submitted: 15 February 2026 You are already at the latest version While recent reviews have firmly established hidradenitis suppurativa (HS) as a systemic inflammatory disorder inextricably linked to metabolic comorbidities, the investigation of lifestyle determinants remains a fraction of the research effort compared to the pursuit of pharmaceuticals.