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Jacey J. Liu on Muck Rack

Jacey J. Liu

As seen in: Cell Reports
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Articles

Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment

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By Wendy S. Chen, Min Zong, Jacey J. Liu
| Cell Reports Verified
Highlights • Myc alone drives a severe HCC phenotype in Shp2-deficient liver • Shp2 is required cell autonomously for control of Myc stability • Shp2 deficiency induces a tumorigenic environment in the liver • Aberrantly elevated β-catenin signaling promotes Myc-driven HCC Summary The mechanisms of Myc-driven liver tumorigenesis are inadequately understood.
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