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Articles by Jack CR
Moth-flame optimized UNet++ with self-attention for early-stage Alzheimer’s disease prediction using multimodal input
Alzheimer’s disease (AD) is a slowly progressing, irreversible neurodegenerative condition that is characterized by the loss of neurons and brain tissue over time. Its impact on patients, caregivers, and society is significant. AD usually results in an inability to carry out daily activities, extensive cognitive impairment, and death. The disease progresses slowly, with symptoms often mistaken for normal aging or minor forgetfulness.
In silico detection of dysregulated genes and molecular pathways in Alzheimer’s disease as basis for food restoring approach
The incidence of age-related diseases, including dementia, is increasing dramatically. Dementia affects 48 million individuals worldwide, with its incidence doubling approximately every five years between the ages of 65 and 90 (Alzheimer’s Association, 2025). In addition, serious concerns are also arising regarding younger population, where increasing acute and chronic abuse of alcohol and other neurotoxic substances is causing serious consequences and irreversible damage to the nervous system.
Predicting amyloid proteins using attention-based long short-term memory
Predicting amyloid proteins using attention-based long short-term memory Punan Branch of Renji Hospital, Shanghai Jiao Tong University, Shanghai, China DOI 10.7717/peerj-cs.2660 Academic Editor Hoang Nguyen Subject Areas Bioinformatics, Artificial Intelligence, Data Mining and Machine Learning, Data Science, Neural Networks Keywords Amyloid, Transformers, Deep learning, LSTM, Alzheimer, Attention Copyright © Licence This is an open access article distributed under the terms of the Creative...
Normalized group activations based feature extraction technique using heterogeneous data for Alzheimer’s disease classification
Alzheimer’s disease (AD) (Alzheimers Association, 2024; Hashmi et al., 2022) is a neurodegenerative disease and is one of the major causes of mortality all over the world. Although the internal damages caused by AD are extensive, it mainly targets memory.
Behind the wheel: exploring gray matter variations in experienced drivers
Behind the wheel: exploring gray matter variations in experienced drivers 1Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, Liaoning, China 2School of Psychology, Guizhou Normal University, Guiyang, Guizhou, China 3Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan, China DOI 10.7717/peerj.17228 Academic Editor Jafri Abdullah Subject Areas Neuroscience, Anatomy and Physiology, Psychiatry and Psychology, Radiology...
Resting heart rate and risk of dementia: a Mendelian randomization study in the international genomics of Alzheimer’s Project and UK Biobank
Resting heart rate and risk of dementia: a Mendelian randomization study in the international genomics of Alzheimer’s Project and UK Biobank 1School of Public Health, Wuhan University, Wuhan, Hubei Province, China 2Duke Kunshan University, Global Health Research Center, Kunshan, Suzhou, China 3The University of Tokyo, Department of Computational Biology and Medical Science, Kashiwa, Japan 4Huazhong University of Science and Technology, Department of Otorhinolaryngology of Union Hospital,...
Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios
Discussion With the continuous increase in the ageing population, the incidence rate of diabetes and its related cognitive dysfunction is gradually increasing. DM-related cognitive impairment is a significant central nervous system complication of DM patients indicated by decreased cognitive ability. The risk of MCI and AD in DM patients is 1.44 and 2.14 times, respectively (Davis et al., 2021).
Heterogeneity of neuroanatomical patterns in prodromal Alzheimer’s disease: links to cognition, progression and biomarkers
Dementia is a prevalent disorder leading to substantial healthcare, financial, and caregiver burden (Hurd et al., 2013). Although Alzheimer’s disease is the most common cause of dementia, several coincident pathologies, mainly vascular lesions, limbic TAR-DNA binding protein-43 (TDP-43, encoded by TARDBP) and Lewy body-related pathology, also account for the cognitive symptoms of dementia subjects (Zanetti et al., 2006; Schneider et al., 2007; Toledo et al., 2013a, b, 2016; Wilson et al., 2013).
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