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Jack PK Bravo

As seen in: Nature, BioRxiv
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Articles

Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles - Nature Communications

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By Jack PK Bravo, Aleksandar Zdravković, Oi Kuan Choong, Niklas Selfjord, Pinar Akcakaya, Michelle J. Porritt, Marcello Maresca, David Taylor, Dmitrii Degtev
| Nature Verified
Abstract Clinical implementation of therapeutic genome editing relies on efficient in vivo delivery and the safety of CRISPR-Cas tools. Previously, we identified PsCas9 as a Type II-B family enzyme capable of editing mouse liver genome upon adenoviral delivery without detectable off-targets and reduced chromosomal translocations. Yet, its efficacy remains insufficient with non-viral delivery, a common challenge for many Cas9 orthologues.
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DNA targeting by compact Cas9d and its resurrected ancestor

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By Jack PK Bravo, Tyler L Dangerfield, Rodrigo Fregoso Ocampo, Isabel Noceda
| BioRxiv
Abstract The type II-A CRISPR effector SpCas9 has gained widespread popularity as an efficient and programmable genome editing tool. However, much remains to be known about novel compact variants that may overcome some limitations of current systems (1,2).
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Unraveling the mechanisms of PAMless DNA interrogation by SpRY Cas9

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By Grace Hibshman, Hongshan Zhang, Tyler L Dangerfield, Jack PK Bravo
| BioRxiv
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