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Oi Kuan Choong

As seen in: Nature, PLOS ONE
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Articles

Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles - Nature Communications

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By Jack PK Bravo, Aleksandar Zdravković, Oi Kuan Choong, Niklas Selfjord, Pinar Akcakaya, Michelle J. Porritt, Marcello Maresca, David Taylor, Dmitrii Degtev
| Nature Verified
Abstract Clinical implementation of therapeutic genome editing relies on efficient in vivo delivery and the safety of CRISPR-Cas tools. Previously, we identified PsCas9 as a Type II-B family enzyme capable of editing mouse liver genome upon adenoviral delivery without detectable off-targets and reduced chromosomal translocations. Yet, its efficacy remains insufficient with non-viral delivery, a common challenge for many Cas9 orthologues.
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SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell carcinoma

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By Rasmus Jakobsson, Anna Grenabo Bergdahl, Oi Kuan Choong, Sofia Brunet
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Abstract The SARS-CoV-2 virus is currently causing a global pandemic. Infection may result in a systemic disease called COVID-19, affecting primarily the respiratory tract. Often the gastrointestinal tract and kidneys also become involved. Angiotensin converting enzyme 2 (ACE2) serves as the receptor for SARS-CoV-2.
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