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Jack Leslie

Buckingham
As seen in: HuffPost, Nature, The Daily Mirror, Aol, Daily Express, Yahoo Finance, Fortune, Gut Journal, The Boston Globe, The Minnesota Star Tribune and
I do Comms/Digital things in F1 💻⌨📱📝🏁🏎
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Articles

Metabolic dysfunction-associated steatotic liver disease and steatohepatitis-associated hepatocarcinoma preclinical models - Nature Reviews Gastroenterology & Hepatology

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By Jack Leslie, Meritxell Huch, Fiona Oakley, Kishore A. Krishnamurthy
| Nature Verified
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses liver steatosis and metabolic dysfunction-associated steatohepatitis (MASH), which can result in fibrosis and/or cirrhosis and increase the risk of hepatocellular carcinoma (HCC). The latest Clinical Practice Guidelines acknowledge the importance of systemic metabolic dysfunction as a driver of hepatic lipid accumulation and disease progression.
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Opinion | When character no longer matters, power becomes the only credential

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By Jack Leslie, Ward Brehm
| The Minnesota Star Tribune Verified
Opinion editor’s note: Strib Voices publishes a mix of guest commentaries online and in print each day. To contribute, click here. ••• The language of our politics has grown reckless. Inflammatory rhetoric and casual cruelty are no longer fringe phenomena; they have crept into the mainstream of our public life. When leaders treat fellow Americans as targets rather than citizens, the damage extends far beyond any single remark.
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Human-correlated genetic models identify precision therapy for liver cancer - Nature

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By Miryam Muller, Stephanie May, Holly Hall, Timothy J. Kendall, Lynn McGarry, Lauriane Blukacz, Sandro Nuciforo, Anastasia Georgakopoulou, Toshiyasu Suzuki, Ian R. Powley, Leah Officer-Jones, Roger Esteban-Fabró, Albert Gris-Oliver, Roser Pinyol, Jack Leslie, Matthew Hoare, Emma Johnson, Misti Vanette McCain, John Halpin, Christos Kiourtis, Colin Nixon, Robin M. Shaw, Daniel Murphy, David Lewis, Helen Reeves, John Le Quesne, Derek A. Mann, Leo M. Carlin, Karen Blyth, Markus H. Heim, Owen J. Sansom, Crispin Miller, Júlia Huguet-Pradell
| Nature Verified
Abstract Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related mortality worldwide1,2. HCC occurs typically from a background of chronic liver disease, caused by a spectrum of predisposing conditions. Tumour development is driven by the expansion of clones that accumulate progressive driver mutations3, with hepatocytes the most likely cell of origin2.
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