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Jacob Aaron Klickstein on Muck Rack

Jacob Aaron Klickstein

As seen in: The Journal of Biological Chemistry
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Articles

AggreCount: an unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially defined manner

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By 'S Choice, Jacob Aaron Klickstein, Sirisha Mukkavalli
| The Journal of Biological Chemistry Verified
Abstract Protein quality control is maintained by a number of integrated cellular pathways that monitor the folding and functionality of the cellular proteome. Defects in these pathways lead to the accumulation of misfolded or faulty proteins that may become insoluble and aggregate over time. Protein aggregates significantly contribute to the development of a number of human diseases such as amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's disease.
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AggreCount: An unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially-defined manner

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By Sirisha Mukkavalli, Malavika Raman, Jacob Aaron Klickstein
| The Journal of Biological Chemistry Verified
Abstract Protein quality control is maintained by a number of integrated cellular pathways that monitor the folding and functionality of the cellular proteome. Defects in these pathways lead to the accumulation of misfolded or faulty proteins that may become insoluble and aggregate over time. Protein aggregates significantly contribute to the development of a number of human diseases such as Amyotrophic lateral sclerosis, Huntington’s and Alzheimer’s Disease.
Open in Who Shared Issue with article?
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