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KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies

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By Pablo Prado, Stephanie Häfner, Yannick Comoglio, Brigitte Wdziekonski, Bernard Attali, Guillaume Sandoz, Christophe Duranton, Jacques Barhanin
| ScienceDirect Verified
Highlights • KCNE1 can serve as an auxiliary subunit of two superfamilies of ion channels • KCNE1 is an auxiliary subunit of the TMEM16A chloride channel • TMEM16A-KCNE1 channel mediates a voltage-gated Cl− current independently of Ca2+ • KCNE1 S38G and R32H polymorphisms abolish the KCNE1-TMEM16A Cl− current Summary Determination of what is the specificity of subunits composing a protein complex is essential when studying gene variants on human pathophysiology.
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