Jadiel Wasson

RESULTS We sought to identify factors involved in communication from the parental environment to progeny in C. elegans. Environmentally supplied double-stranded RNA (dsRNA) induces gene silencing in the next generation, providing a useful assay (4). We fed mothers diluted dsRNA for the essential gene pha-4, which generated weak silencing in the progeny in wild-type animals, and screened for mutants that enhanced RNA interference (RNAi) potency.

New Results Jadiel A. Wasson, Gareth Harris, Sabine Keppler-Ross, Trisha J. Brock, Abdul R. Dar, Rebecca A. Butcher, Sylvia E.J. Fischer, Konstantinos Kagias, Jon Clardy, Yun Zhang, View ORCID ProfileSusan E. Mango doi: https://doi.org/10.1101/2021.02.01.429208 Abstract Mothers contribute cytoplasmic components to their progeny in a process called maternal provisioning.

Right after fertilization, embryos at the earliest stages of development tell their genes: "Forget what it was like in the sperm or egg where you came from." When the process of epigenetic reprogramming is defective in mouse development, the consequences in adulthood can include abnormal repetitive behaviors, scientists have shown. Their findings are published online in the journal eLife.