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Jae Ryong Lim on Muck Rack

Jae Ryong Lim

As seen in: Nature, Journal of Biomedical Science
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Articles

Apelin-13 prevents GATA4-mediated neuronal senescence by restoring autophagy through mTORC1 inhibition

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By Su Han, Ji Hyeon Cho, Jae Ryong Lim, Ji Yong Park, Han Chang, Chang Woo Chae, Young Hyun Jung, Ho Han, Jee Hyeon Yoon, Su Yeol Kim, Ha Jin Kim, Seung Gyu Lee, Jong Hwa Yun
| Nature Verified
Abstract Neuronal senescence, triggered by oxidative stress and inflammatory responses, is a significant risk factor for brain aging, ultimately leading to cognitive decline. Apelin-13, an exercise-induced myokine, exhibits potential neuroprotective effects by the APJ system, but its protective effects against neuronal senescence and the underlying mechanisms are unknown.
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