Jahnavi Rajan

Keywords replication stress reversed replication forks fork protection inflammation DNA sensing IFI16 STING BRCA1 BRCA2 MRE11 NF-κB IL-6 Introduction Replication stress arises in response to a wide range of perturbations, including nucleotide pool imbalance, polymerase inhibition, replisome encounter with the transcription machinery, or treatment with genotoxic agents.1 Replication stress-induced DNA damage and genome instability are counteracted by a range of mechanisms that facilitate the...