Jaichandar Subramanian

Abstract Alzheimer's disease patients and mouse models exhibit aberrant neuronal activity and altered excitatory-to-inhibitory synaptic ratio. Using multicolor two-photon microscopy, we test how amyloid pathology alters the structural dynamics of excitatory and inhibitory synapses and their adaptation to altered visual experience in vivo in the visual cortex. We show that the baseline dynamics of mature excitatory synapses and their adaptation to visual deprivation are not altered in amyloidosis.

Abstract Familiarity creates subjective memory of repeated innocuous experiences, reduces neural and behavioral responsiveness to those experiences, and enhances novelty detection. The neural correlates of the internal model of familiarity and the cellular mechanisms of enhanced novelty detection following multi-day repeated passive experience remain elusive.

Introduction Alzheimer’s disease (AD) is a progressive neurological disorder characterized by the degeneration of cognitive functions or dementia, with an often overlooked but significant impact on sensory modalities such as vision, hearing, smell and touch (Albers et al., 2015; Claire, 2019; Wiesman et al., 2021a).