Jakob El Kholtei on Muck Rack

Jakob El Kholtei

As seen in: Cell Press
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Articles

Whole-embryo Spatial Transcriptomics at Subcellular Resolution from Gastrulation to Organogenesis

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By Yinan Wan, Jakob El Kholtei, Ignatius Jenie, Mariona Colomer-Rosell
| biorxiv.org
Abstract Spatiotemporal patterns of gene expression underlie embryogenesis. Despite progress in single-cell genomics, mapping these patterns across whole embryos with comprehensive gene coverage and at high resolution has remained elusive. Here, we introduce a whole-embryo imaging platform using multiplexed error-robust fluorescent in-situ hybridization (weMERFISH). We quantified the expression of 495 genes in whole-mount zebrafish embryos at subcellular resolution.
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Emergence of Neuronal Diversity during Vertebrate Brain Development

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By Bushra Raj, Jeffrey A. Farrell, Jialin Liu, Jakob El Kholtei
| Cell Press Verified
Allende M.L. Weinberg E.S. The expression pattern of two zebrafish achaete-scute homolog (ash) genes is altered in the embryonic brain of the cyclops mutant. Dev. Biol. 1994; 166: 509-530 Bendall S.C. Davis K.L. Amir A.D. Tadmor M.D. Simonds E.F. Chen T.J. Shenfeld D.K. Nolan G.P. Pe’er D. Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell. 2014; 157: 714-725 Boije H. Rulands S. Dudczig S.
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