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James AC Bertlin on Muck Rack

James AC Bertlin

As seen in: BioRxiv
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Articles

VHL synthetic lethality screens uncover CBF-beta as a negative regulator of STING

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By Tekle Pauzaite, Qian Liang, Niek Wit, James AC Bertlin
| BioRxiv
Abstract Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of VHL, and uncover that loss of Core Binding Factor beta (CBF-beta) causes cell death in VHL-null ccRCC cell lines and impairs tumour establishment and growth in vivo.
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