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Tekle Pauzaite on Muck Rack

Tekle Pauzaite

As seen in: Nature, BioRxiv
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Articles

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING

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By Tekle Pauzaite, Qian Liang, Niek Wit, James Williamson, Nicholas J Matheson, Brian M. Ortmann, Thomas Mitchell, Anneliese O. Speak, Qing Zhang, James Nathan, James A. C. Bertlin, Jia Jhing Sia
| Nature Verified
Abstract Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of VHL, and uncover that loss of Core Binding Factor β (CBF-β) causes cell death in VHL-null ccRCC cell lines and impairs tumour establishment and growth in vivo.
Open in Who Shared Issue with article?

VHL synthetic lethality screens uncover CBF-beta as a negative regulator of STING

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By Tekle Pauzaite, Qian Liang, Niek Wit, James AC Bertlin
| BioRxiv
Abstract Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of VHL, and uncover that loss of Core Binding Factor beta (CBF-beta) causes cell death in VHL-null ccRCC cell lines and impairs tumour establishment and growth in vivo.
Open in Who Shared Issue with article?

Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response

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By Niek Wit, Rachel V. Seear, James A. Nathan, Tekle Pauzaite
| BioRxiv
Abstract The ubiquitination and proteasome-mediated degradation of Hypoxia Inducible Factors (HIFs) is central to metazoan oxygen-sensing, but the involvement of deubiquitinating enzymes (DUBs) in HIF signalling is less clear. Here, using a bespoke DUBs sgRNA library we conduct CRISPR/Cas9 mutagenesis screens to determine how DUBs are involved in HIF signalling.
Open in Who Shared Issue with article?
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