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Serum IgA and IgM levels in hemochromatosis probands with HFE p.C282Y homozygosity
Loading metrics Open Access Peer-reviewed Research Article Citation: Barton JC, Barton JC, Bertoli LF, Acton RT (2026) Serum IgA and IgM levels in hemochromatosis probands with HFE p.C282Y homozygosity. PLoS One 21(6): e0352148. https://doi.org/10.1371/journal.pone.0352148 Editor: Mohamed Salama, Mansoura University Faculty of Veterinary Medicine, EGYPT Received: March 1, 2025; Accepted: June 6, 2026; Published: June 24, 2026 Copyright: © 2026 Barton et al.
A Decreasing North-to-South Gradient of HFE p.C282Y (rs1800562) Allele Frequencies in Iberia: An Analysis of 33 Population/Control Cohorts
Background: We sought to analyze the geographic distribution of HFE p.C282Y (homeostatic iron regulator c.845G>A; rs1800562) allele frequencies in Iberia. Methods: We analyzed published population/control cohorts of 50 or more subjects in mainland Spain and mainland Portugal and determined whether or not the p.C282Y genotypes in each cohort deviated from Hardy-Weinberg equilibrium (HWE) proportions. We defined combined p.C282Y allele frequencies from Spain and Portugal as representative of Iberia.
Prevalence of Iron Deficiency Using 3 Definitions Among Women in the US and Canada
Key Points Question Is the definition of iron deficiency, a common disorder that causes substantial morbidity in women, significantly associated with population prevalence estimates of iron deficiency? Findings In this cross-sectional, primary care–based study of 62 685 women in the US and Canada, 3 definitions of iron deficiency were associated with significantly different prevalence rates of iron deficiency, regardless of self-reported age, pregnancy, or race and ethnicity.
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