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Trypsin-catalyzed asymmetric aldol reactions of isatins with cyclic ketones and the mechanistic insights on activity differences at theoretical level
Enzyme catalysis is regarded as an indispensable tool in modern organic synthesis (Hanefeld et al., 2022, Romero et al., 2023). In comparison with the chemical methods, the biological nature makes it a vibrant participant to access products, for instance mild conditions, exquisite selectivity and environmental benign (Simic et al., 2022, Wu et al., 2021).
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