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James Nichols on Muck Rack

James Nichols

As seen in: Nature, BioRxiv, This is Money, JD Supra, Texas Medical Center, FE Investegate, Archives of Pathology, Omnia Health
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Articles

The alx gene family confers segmental identity to frontonasal cranial neural crest cells

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By Abigail Mumme-Monheit, Jennyfer M Mitchell, Raisa Bailon-Zambrano, Nadia H. Wright, Margaret Keating, Colette Hopkins, Kent A. Riemondy, Grace E. Gustafson, Nicole Moss, Daniel Medeiros, James Nichols, Lindsey A. Neukirch
| Nature Verified
Abstract Cranial neural crest cells in the pharyngeal arches give rise to vertebrate head skeletal structures. Hox genes confer segmental identity to the different arches, and Hox mutations result in mirror-image homeotic duplications. Frontonasal cranial neural crest cells reside anterior to the first pharyngeal arch, give rise to the midface skeleton, and are not considered part of the segmental series.
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Holdings in Company

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By Matthew Nichols, James Nichols, John Nichols, Katharine Kropp
| sharesmagazine.co.uk
RNS Number : 7563J Nichols PLC 01 December 2025 NICHOLS PLC (the "Company" or "Group") HOLDINGS IN COMPANY The Nichols Concert Party announces that, following the transfer by John Nichols of 500,000 ordinary shares to each of his three children (1.5 million shares in total) on 25 November 2025, the Nichols Concert Party holding remains unchanged with interests in 13,122,925 Ordinary Shares of 10p each, representing 35.89% of the current total voting rights.
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Fitness Landscape Ruggedness Arises from Biophysical Complexity

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By Matthew Spence, Mahakaran Sandhu, Dana Matthews, James Nichols
| BioRxiv
Abstract Epistasis, in which the effect of a mutation depends on the genetic background it is introduced into, drives protein evolution and design by shaping the fitness landscape. Quantifying how constrained by epistasis (and thus rugged) a fitness landscape is when data is combinatorially incomplete, however, remains challenging. Here, we propose a spectral graph theory approach to measure fitness landscape ruggedness as the characteristic time step of a heat diffusion process.
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