Matthew Spence on Muck Rack

Matthew Spence

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As seen in: Medium, The Washington Post, Wiley Online Library, MDPI, Stars and Stripes, Stanford Social Innovation Review, eLife, The Journal of Pediatrics, Greene County Messenger, Herald Standard and
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Articles

Sheriff to increase speed enforcement in school zones

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By Barry Johanson, Matthew Spence
| Plymouth Review
As the school year begins, the safety of our children, families, and school staff is a top priority. Driving at safe speeds and staying attentive behind the wheel—especially in and around school zones—is not just responsible behavior, it’s a matter of public safety. Excessive speed and distracted driving significantly increase the risk of accidents, particularly during school start and release […] Remember Me
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Investigating the determinants of performance in machine learning for protein fitness prediction

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By Mahakaran Sandhu, Adam C Mater, Dana Matthews, Matthew Spence
| Wiley Online Library
1 INTRODUCTION In recent years, machine learning has transformed many domains of science, including protein biology and engineering. Models such as AlphaFold have solved decades-long problems in protein structure prediction (Abramson et al. 2024; Jumper et al.
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Fitness Landscape Ruggedness Arises from Biophysical Complexity

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By Matthew Spence, Mahakaran Sandhu, Dana Matthews, James Nichols
| biorxiv.org
Abstract Epistasis, in which the effect of a mutation depends on the genetic background it is introduced into, drives protein evolution and design by shaping the fitness landscape. Quantifying how constrained by epistasis (and thus rugged) a fitness landscape is when data is combinatorially incomplete, however, remains challenging. Here, we propose a spectral graph theory approach to measure fitness landscape ruggedness as the characteristic time step of a heat diffusion process.
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