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James Wilson

As seen in: Medium, The New York Times, Nature, The Wall Street Journal, Memory Studies, OUPblog, Environmental Communication, MDPI, SAGE Publishing, The Conversation and
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Articles

Genetic ancestry and monogenic disease risk in the Scottish Traveller founder population

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By Ashwini Shanmugam, Benjamin Fletcher, Maria Pala, Lucija Klaric, Shona M. Kerr, Samantha Donaldson, Gannie Tzoneva, Alan R. Shuldiner, Martin Richards, Russell McLaughlin, Gianpiero Cavalleri, Ross Byrne, Edmund Gilbert, James WIlson, James Wilson
| Nature Verified
Abstract The Scottish Travellers are a traditionally nomadic community in Scotland that has historically been marginalised, and remained socially isolated from the settled Scottish population until recently. Little, however, is known about their genetic origins, population structure and risks of Mendelian disease.
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Systematic characterisation of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

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By Hao Jiang, Jimena Druker, James WIlson, James Wilson
| eLife
eLife Assessment The study presents a valuable resource of proline hydroxylation proteins for molecular biology studies in oxygen-sensing and cell signaling with the characterization of Repo-man proline hydroxylation site. The evidence supporting the claim of the authors is solid, although further clarification of the overall efficiency of the HILIC analysis, the specificity/sensitivity of immonium ion analysis, as well as quantification of proline hydroxylation identifications will be helpful.
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Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes - Nature Medicine

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By Go Sato, Yuji Yamamoto, Kyuto Sonehara, Ryunosuke Saiki, Takafumi Ojima, Masahiro Kanai, Aoxing Liu, Ryuya Edahiro, Yuya Shirai, Shinichi Namba, Ho Namkoong, Takanori Hasaegawa, Yuriko N. Koyanagi, Yumiko Kasugai, Taiki Yamaji, Shiori Nakano, Giulio Genovese, Timo Sipilä, Awaisa Ghazal, Hiromu Tanaka, Shuhei Azekawa, Yoshifumi Uwamino, Kenichi Yamamoto, Ken Suzuki, Tsuyoshi Hata, Mamoru Uemura, Yoshito Takeda, Akinori Kanai, Shinichi Higashiue, Shuzo Kobayashi, Hisaaki Afuso, Kosho Matsuura, Yojiro Mitsumoto, Yasuhiko Fujita, Yoshiya Oda, Yutaka Suzuki, Takayuki Morisaki, Makoto Ishii, Yuko Kitagawa, Ryuji Koike, Akinori Kimura, Seiya Imoto, Satoru Miyano, Takanori Kanai, Jun Takayama, Motoki Iwasaki, Norie Sawada, Koichi Fukunaga, Keitaro Matsuo, Atsushi Kumanogoh, Yuichiro Doki, Hidetoshi Eguchi, Shigeki Nakagome, Andrea Ganna, Aarno Palotie, Mark Daly Verified, James WIlson, James Wilson, Masayuki Yamamoto, Koichi Matsuda, Seishi Ogawa, Toshimasa Yamauchi, Takashi Kadowaki, Yukinori Okada
| Nature Verified
Abstract Our understanding of the biological role of the Y chromosome remains limited. Here, we systematically profile germline Y haplogroups and somatic loss of the Y chromosome (LOY) in 122,683 East Asian males from BioBank Japan and 181,472 European males from the UK Biobank. A phenome-wide scan uncovers male-specific genetic regulation of complex traits, including pleiotropic effects of the Japanese-specific haplogroup D on height and type 2 diabetes (T2D).
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