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Articles by Jan Attig
RIXS observation of bond-directional excitations in the Kitaev material Na 2 IrO 3
Abstract Spin-orbit coupling locks spin direction and spatial orientation and generates, in semi-classical magnets, a local spin easy-axis and associated ordering. Quantum spin-1/2’s defy this fate: rather than spins becoming locally anisotropic, the spin-spin interactions do. Consequently interactions become dependent on the spatial orientation of bonds between spins, prime theoretical examples of which are Kitaev magnets.
Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy - Nature
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The authors have retracted this article. An investigation by The Francis Crick institute found concerns regarding some of the data presented in the figures, specifically: 1. The A549 cell binding data in Fig. 5c are manipulated and could not be reproduced. 2. The antibody-dependent cellular cytotoxicity (ADCC) experiments shown in Fig. 5d and 5e may contain manipulated data. 3. The integrity of the source data for the B cell and antibody quantitation in Fig. 3c and Extended Data Fig.
By Jorge Almagro, Oriol Pich, Takahiro Karasaki, Roberto Salgado, George Young, Miriam Molina-Arcas, Jan Attig, Sophia Ward, Alexander Frankell, Maise Al Bakir, Mark Hill, Daniel Cook, Nicolai J. Birkbak, Axel Behrens, Sanjay Popat, Allan Hackshaw, TRACERx consortium, Kevin Litchfield, Nicholas McGranahan, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward
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Nature
Verified
Human endogenous retrovirus onco-exaptation counters cancer cell senescence through Calbindin
ResearchIn-Press PreviewGeneticsOncology Open Access | 10.1172/JCI164397 J Clin Invest. https://doi.org/10.1172/JCI164397. Copyright © 2023, Attig et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterizes most cancer types, linked with disease outcomes.
Antibodies against endogenous retroviruses promote lung cancer immunotherapy - Nature
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Abstract B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive1,2.
By Jorge Almagro, Oriol Pich, Takahiro Karasaki, Roberto Salgado, George Young, Miriam Molina-Arcas, Jan Attig, Sophia Ward, Alexander Frankell, Maise Al Bakir, Mark Hill, Daniel Cook, Nicolai J. Birkbak, Axel Behrens, Sanjay Popat, Allan Hackshaw, TRACERx consortium, Kevin Litchfield, Nicholas McGranahan, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward
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Nature
Verified
Intergenic RNA mainly derives from nascent transcripts of known genes
Genome Biology volume 22, Article number: 136 (2021) Cite this article Abstract Background Eukaryotic genomes undergo pervasive transcription, leading to the production of many types of stable and unstable RNAs. Transcription is not restricted to regions with annotated gene features but includes almost any genomic context. Currently, the source and function of most RNAs originating from intergenic regions in the human genome remain unclear.
Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option
Abstract Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a regulator of several physiological processes. ACE2 has recently been proposed to be interferon (IFN) inducible, suggesting that SARS-CoV-2 may exploit this phenomenon to enhance viral spread and questioning the efficacy of IFN treatment in coronavirus disease 2019.
Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression
Anastasiya Kazachenka1, George R.
Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
Abstract Immune regulation is a finely balanced process of positive and negative signals. PD-L1 and its receptor PD-1 are critical regulators of autoimmune, anti-viral and anti-tumoural T cell responses. Although the function of its predominant membrane-bound form is well-established, the source and biological activity of soluble PD-L1 (sPD-L1) remain incompletely understood.
Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing
(A) For each RBP that showed considerable binding to LINE repeats in iCLIP (see B), we selected the 50 LINE repeats with strongest coverage (cDNAs per 100nt). For comparison we included TARDBP, which showed little binding to LINE repeats. All iCLIP data selected was collected from HEK293 cells. The heatmap shows comparison of binding strength at this set of 214 LINE repeats, and the nearest neighbor analysis for each RBP.
Erratum to: Insights into the design and interpretation of iCLIP experiments
All iCLIP data that were newly generated for this manuscript are made available at http://www.ebi.ac.uk/arrayexpress/ via accession numbers E-MTAB-5027 (PTBP1-iCLIP2), E-MTAB-5026 (PTBP1-iCLIP3), E-MTAB-3618 (eIF4A3-iCLIP2) and E-MTAB-4000 (eIF4A3-iCLIP3). This has now been acknowledged and corrected in this erratum. The publisher apologises for these errors.
Insights into the design and interpretation of iCLIP experiments
Crosslink sites are identified by cDNA-starts in iCLIP ). First, cells or tissues are irradiated with UV light, which can create covalent bonds between an RBP and RNA. Cell lysates are then treated with RNase and the crosslinked RNA fragments are co-immunoprecipitated with the RBP. In the third step, an oligonucleotide adapter is ligated to the 3? end of RNA fragments.
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