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Jan C Kamp on Muck Rack

Jan C Kamp

As seen in: Nature, MDPI, ACS Publications, Science Magazine, The Lancet, EBioMedicine, European Respiratory Journal
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Articles

Genomic profiling identifies actionable DNA-repair defects in a new cervical cancer model

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By Robert Polten, Ivana Kutle, Jan Lennart Stalp, Jens Hachenberg, Philipp John-Neek, Dhanya Ramachandran, Lara Kokemüller, Doris Steinemann, Jonathan L. Lühmann, Yvonne Behrens, Gudrun Göhring, Stephan Bartels, Malte Gronewold, Lavinia Neubert, Jan C Kamp, Dirk Schaudien, Robert Geffers, Peter Hillemanns, Thilo Dörk, Rüdiger Klapdor, Michael Morgan, Axel Schambach, Ann-Kathrin Seyda, Rafaela Schmidtke, Valeriia Obrizan
| Nature Verified
Abstract Genetic profiling of a new HPV-negative cervical cancer model identified pathogenic variants in genes implicated in oncogenic signaling, cell cycle regulation, and DNA damage repair pathways, including homologous recombination, non-homologous end-joining, and mismatch repair. Deficiencies in BRCA2, RAD51 and MLH1 were among these actionable targets.
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The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis

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By Neus Martínez-Bosch, Nithik Chintalacheruvu, Edismauro Garcia Freitas-Filho, Jannik Ruwisch, Aurélie Cazes, Lena M Leiber, Raphael Borie, Lavinia Neubert, Leonard Christian, Vincent Thomas de Montpréville, Adam Szmul, Farah Moussa, Stijn E. Verleden, Svenja Gaedcke, Jan Hegermann, Jan Fuge, Matthias Ballmaier, Jan C Kamp, Mark Greer, Peter Braubach, Christopher Werlein, Theresa Graalmann, Laurens J. De Sadeleer, Fabius Ius, Kalil Aburahma
| Science Magazine Verified
Abstract Pleuroparenchymal fibroelastosis (PPFE) is a progressive interstitial lung disease (ILD) with defining histology of intra-alveolar fibrosis with septal elastosis (AFE), suggesting unique cellular disease processes. Here, we present a binational single-nucleus RNA sequencing atlas of PPFE, based on explanted lungs from 40 patients.
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Occurrence, Temporal Variability, and Loads of Poly(vinyl chloride) in the Rhine and Moselle

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By Jan C Kamp, Georg Dierkes, thomas hoffmann, David Range
| ACS Publications
1. Introduction Click to copy section linkSection link copied! Plastic, a diverse class of synthetic polymers, has become omnipresent in modern life due to its versatility, durability, and cost-effectiveness. The most commonly produced plastics, with annual production volumes of up to 75.6 Mt, are polyethylene (PE), polypropylene (PP), poly(vinyl chloride) (PVC), polystyrene (PS), polyethylene terephthalate (PET), polycarbonate (PC), and acrylonitrile butadiene styrene (ABS).
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