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Articles by Jan Eberhardt
A distant brown dwarf coplanar to a warm Jupiter and a hot super-Earth
Abstract In transiting planetary systems, in which planetary sizes are accurately determined from transit observations, the presence of transit-timing variations1 (TTVs), especially when combined with radial velocity (RV) data, provides powerful constraints on masses and orbital eccentricities. Together, these measurements offer crucial insights into system architecture, formation mechanisms and dynamical evolution.
Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals
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Keywords influenza virus H5N1 highly pathogenic avian influenza clade 2.3.4.4b A/Texas/37/2024 humoral immunity pre-existing antibodies cross-neutralizing antibodies Introduction Sporadic human infections with highly pathogenic avian influenza A virus (HPAIV) H5N1 were first documented by spillover from birds to humans in 1997, followed by repeated outbreaks among birds with a total of 954 human cases leading to 464 deaths (48.6% case-fatality rate) between 2003 and 2024.1 In March 2024, the...
By Katharina Daniel, Leon Ullrich, Denis Ruchnewitz, Matthijs Meijers, Nico Halwe, Ursula Wild, Jan Eberhardt, Jacob Schön, Marie Wunsch, Maryna Kuryshko, Christopher R. Dietrich, Christian Kukat, Lutz Gieselmann, Henning Gruell, Donata Hoffmann, Martin Beer, Thomas C. Erren, Michael Lässig, Christoph Kreer, Florian Klein, Ricarda Stumpf, Maike Schlotz, Luana Girao Lessa, Elsayed Mohammed Abdelwhab, Andreas Pinger, Anna-Lena Schumacher, Maximilian Germer, Malena Rohde
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Cell Press
Verified
Concepts and methods for predicting viral evolution
Abstract The seasonal human influenza virus undergoes rapid evolution, leading to significant changes in circulating viral strains from year to year. These changes are typically driven by adaptive mutations, particularly in the antigenic epitopes, the regions of the viral surface protein haemagglutinin targeted by human antibodies. Here we describe a consistent set of methods for data-driven predictive analysis of viral evolution.
Population immunity predicts evolutionary trajectories of SARS-CoV-2
Highlights • SARS-CoV-2 variants compete on a fitness landscape shaped by population immunity • Immune-induced fitness is computable from genetic, epidemic, and cross-protection data • A fitness model predicts viral frequency changes and predominance shifts • Time-dependent selection windows constrain the antigenic profile of emerging variants Summary The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of genetic clades.
Seeing What You Normally Don't See
Seeing What You Normally Don't See Abstract Video can be a powerful tool to support teacher research, help teachers notice what's not readily visible in their daily teaching, transform their practice, and improve student learning. © 2010 Phi Delta Kappa International
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