Jan-Hinnerk Saathoff on Muck Rack

Jan-Hinnerk Saathoff

As seen in: Cell Press
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Articles

Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex

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By Lisa Käshammer, Jan-Hinnerk Saathoff, Katja Lammens, Fabian Gut
| Cell Press Verified
Highlights • cryo-EM structure of EcMre11-Rad50 bound to a DNA break • Mre11 dimer binds the DNA end at the side of Rad50 • Mre11 and Rad50 assemble a transient DNA cutting channel • The coiled coils form a rod-shaped DNA gate and clamp Summary DNA double-strand breaks (DSBs) threaten genome stability throughout life and are linked to tumorigenesis in humans.
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