Jan Tesarik

This version is not peer-reviewed. Submitted: 07 December 2025 You are already at the latest version Ovarian aging (OA) results from senescence of different cell types present in the ovary, decreases female fertility and quality of life and augments the risk of a variety of fertility-unrelated pathological conditions.

LetterArticles in Press105412 MARGen Clinic, 18002 Granada, Spain Publication History: Received November 7, 2025; Accepted November 13, 2025; Published online November 20, 2025 DOI: 10.1016/j.rbmo.2025.105412 External LinkAlso available on ScienceDirect External Link Copyright: © 2025 Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd. I read with interest the article by Rottiers et al.

This version is not peer-reviewed. You are already at the latest version Many experimental and clinical studies published so far demonstrate that melatonin can be used with success in the treatment of different types of human female infertility, improving oocyte developmental competence and uterine receptivity for the implanting embro, preventing immune rejection of the implanting embryo and spontaneous pregnancy loss, and alleviating symptoms of endometriosis and adenomyosis.