Janbolat Ashim on Muck Rack

Janbolat Ashim

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Articles

Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction

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By Kiae Kim, Donghee Ham, Wookyung Yu, Janbolat Ashim
| Cell Press Verified
Arrestins interact with phosphorylated G protein-coupled receptors (GPCRs) and regulate the homologous desensitization and internalization of GPCRs. The gate loop in arrestins is a critical region for both stabilization of the basal state and interaction with phosphorylated receptors. We investigated the roles of specific residues in the gate loop (K292, K294, and H295) using β-arrestin-1 and phosphorylated C-tail peptide of vasopressin receptor type 2 (V2Rpp) as a model system.
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