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Javier Pagonabarraga on Muck Rack

Javier Pagonabarraga

As seen in: Nature, Wiley Online Library, MDPI, La Verdad de Murcia
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Articles

Minimal clinically important difference for cognitive scales in people with Parkinson’s disease with cognitive impairment

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By Ghorban Taghizadeh, Negin Eissazade, Javier Pagonabarraga, Saül Martínez-Horta, Jaime Kulisevsky, Seyede Zohreh Jazaeri, Maryam Mehdizadeh, Azar Sharabiani, Pouria Akbarikoli
| Nature Verified
Abstract Cognitive impairment (CI) is a significant non-motor symptom of Parkinson’s disease (PD), necessitating effective assessment tools to evaluate treatment efficacy. Minimal Clinically Important Difference (MCID) thresholds provide critical benchmarks for interpreting cognitive intervention outcomes. This study establishes MCID values for PD Cognitive Rating Scale (PD-CRS), Scales for Outcomes in PD-Cognition (SCOPA-COG), and Montreal Cognitive Assessment (MoCA) in PD-CI.
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Unraveling the genetic architecture of non-Huntington chorea: a biobank-scale study of rare variants and repeat expansions

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By Fulya Akçimen, Monica Diez-Fairen, Ignacio Álvarez, Victor Puente Verified, spencer grant, Jorge Hernández-Vara, Marzieh Khani, Mariateresa Buongiorno, Félix Javier Jiménez-Jiménez, José A. G. Agúndez, Miquel Aguilar, Esther Cubo, Jesus Perez, Jesús Pérez, Javier Pagonabarraga, Nuria Caballol, Jinhui Ding, Elena García-Martín, Hortensia Alonso-Navarro, Yaroslau Compta, Carlos Cruchaga, Katrin Beyer, J. Raphael Gibbs, Andrew Singleton, Sara Bandrés-Ciga, Asuncion Avila
| Nature Verified
Abstract Chorea can arise from genetic, metabolic, pharmacologic, and autoimmune causes. In clinical practice, however, non-genetic causes are rare. The most common genetic cause is a CAG repeat expansion in HTT, leading to Huntington’s disease (HD). Beyond HD, systematic studies have been lacking and many individuals with non-HD chorea remain without a molecular diagnosis.
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CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

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By Jon Rodríguez-Antigüedad, Arnau Puig-Davi, Iñigo Ruiz-Barrio, Javier Pagonabarraga
| Wiley Online Library Verified
1 Introduction Cognitive impairment is a common and disabling non-motor symptom in Parkinson's Disease (PD) that can occur at any stage of the disease [1]. Attention, working memory, and executive functions are the most prominently affected domains in the early stages, whereas language, visuospatial, and memory impairment generally appear in the later stages [2].
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