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Jawariya Mobin

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Articles

Development of thiazole-based α-amylase inhibitors: synthesis, in vitro evaluation, and computational insights via DFT and molecular docking

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By Amina Fayaz, Aftab Alam, Ajmal Shah, Ahmed A. Elhenawy, Abdullah F Alasmari, Fawaz Alasmari, Jawariya Mobin
| Nature Verified
Abstract In this research, a new series of thiazole-based hydrazone derivatives (9–14) was designed, synthesized, and evaluated for α-amylase inhibitory activity as a strategy to manage postprandial hyperglycemia in type 2 diabetes (T2DM). The target compounds were obtained via a two-step procedure: condensation of thiosemicarbazide with substituted aromatic aldehydes to form hydrazones, followed by cyclization with phenacyl bromide.
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