Jayanth Kumar Palanichamy

Abstract Mitophagy is a selective form of autophagy that plays a crucial role in mitochondrial quality control. Mediators of the mitophagy pathway have been reported to contribute to tumor progression in multiple solid tumors. Limited data suggests that the overexpression of certain pathway components may predict for adverse survival outcomes in adult AML. However, the role of these mediators in pediatric AML has not been studied previously.

Abstract N-6 Methyl Adenosine (m6A) methylation is primarily found in the 3'-UTRs of mRNAs, near the stop codon, and at consensus sequence RRACH. The methylation reaction is catalyzed by RNA methyltransferases METTL3 and METTL14, known as writers. Readers recognize the modified mRNA, which influences mRNA stability and translation. Insulin-like growth factor-2 binding proteins 1 and 3 (IGF2BP1 and IGF2BP3) are known m6A readers, promoting mRNA stabilization.

Role of miRNAs identified in EBC samples as diagnostic biomarkers in lung cancer Accumulating evidence suggests that miRNAs in EBC samples could be used as potential diagnostic biomarkers for lung cancer. In one of the earliest reports on the role of miRNAs in lung cancer, Mozzoni et al. [72] included 46 control subjects and 54 confirmed NSCLC patients. The NSCLC group comprised 37 adenocarcinoma and 17 squamous cell carcinoma cases, with the majority being early-stage disease.