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Jayne A. Barbour on Muck Rack

Jayne A. Barbour

As seen in: BioRxiv, European Journal of Cancer
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Articles

Integrating long-read RNA sequencing improves locus-specific quantification of transposable element expression

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By SoJung Lee, Jayne A. Barbour, Haocheng YANG, Yuanhua Huang
| BioRxiv
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Global and local redistribution of somatic mutations enable the prediction of functional XPD mutations in bladder cancer

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By Jayne A. Barbour, Tong Ou, Hu Fang, Noel Yue
| BioRxiv
Abstract Xeroderma pigmentosum group D (XPD) is a DNA helicase with critical functions in transcription initiation and nucleotide excision repair. Missense mutations in XPD are putative drivers in around 10% of bladder cancers (BLCA), but the associated mutational process remains poorly understood. Here, we examine the somatic mutational landscape of XPD wild-type (n=343) and mutant (n=39) BLCA whole genomes.
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Overexpression of transposable elements is associated with immune evasion and poor outcome in colorectal cancer

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By Xiaoqiang Zhu, Hu Fang, Kornelia Gladysz, Jayne A. Barbour
| European Journal of Cancer Verified
Highlights • Transposable element (TE) expression predicts survival in patients with colorectal cancer. • TE expression is associated with immune cell infiltration independent of microsatellite instability status. • TE overexpression drives programmed death-ligand 1 expression in immune cells leading to immune evasion. • A TE expression score can be used to subtype of patients with colorectal cancer.
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