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Jean-Charles Nault on Muck Rack

Jean-Charles Nault

As seen in: Nature, Gut Journal, MDPI, The Conversation, The Lancet, Cell Reports Medicine, HAL, Future Medicine, JHEP Reports, The Classical Mind
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Articles

Integrated genomic analyses identify oncogenic pathway interplay in hepatocarcinogenesis defining specific molecular subtypes

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By Long Pan, Theo Z Hirsch, Jing Fang, Agnieszka Seretny, Sandrine Imbeaud, Shuoshuo Jin, Sandra Rebouissou, Julien Calderaro, Giuliana Amaddeo, Jean-Frédéric Blanc, Brigitte Le Bail, Marianne Ziol, Séverine Celton-Morizur, Valérie Paradis, Josep M Llovet, Darjus Felix Tschaharganeh, Jean-Charles Nault, Chantal Desdouets, Stefano Caruso, Jessica Zucman-Rossi, Olatunji Oluwole Gege, Sabrina Sidali, Naïma Ammiche
| Nature Verified
Abstract Hepatocellular carcinoma (HCC) is a genomically diverse disease, and molecular classification is essential for understanding its biology and improving patient care. Here, integrative analyses of 529 HCC samples across genomic, transcriptomic, epigenomic, and proteomic layers identify nine robust molecular subtypes, validated in 807 external cases.
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The role of [ 18 F]FDG and [ 18 F]FCH PET-CT in hepatocellular carcinoma with cirrhosis – Author's reply

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By Jean-Charles Nault, Hôpital Avicenne, Unité de Formation
| The Lancet Verified
FREE with registration! Log in or register to access the full article. References 1. Nault, JC ∙ Boubaya, M ∙ Wartski, M ∙ et al. [18F]fluorodeoxyglucose and [18F]fluorocholine PET-CT for staging optimisation and treatment modification in hepatocellular carcinoma (PET-HCC01): a prospective multicentre study Lancet Gastroenterol Hepatol. 2025; 10:306-314 2. Sönmez, RE ∙ Besson, FL ∙ Ghidaglia, J ∙ et al.
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Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis - Nature Reviews Gastroenterology & Hepatology

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By Eric Trépo, Jessica Zucman-Rossi, Jean-Charles Nault
| Nature Verified
Abstract Steatotic liver diseases, encompassing metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease, affect nearly one-third of the global population and are a leading cause of cirrhosis and hepatocellular carcinoma. The substantial interindividual variation in disease progression indicates important genetic contributions beyond environmental factors.
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