Jean-Philippe Fortin

Abstract Protein phosphatase 2A (PP2A) is a Ser/Thr phosphatase that regulates the phosphorylation of almost all cellular processes, including cell division and proliferation1,2. PP2A forms heterotrimeric holoenzyme complexes comprising a catalytic subunit (PP2Ac), a scaffolding subunit (PP2Aa) and variable B regulatory subunits that exert precise control over enzyme substrate specificity and prevent indiscriminate dephosphorylation of phosphoproteins3.

Keywords microglia Alzheimer’s disease neurodegeneration Ptpn6 SHP-1 white matter plaque galectin-3 genome-wide screen single-cell RNA-seq Get full text access Log in, subscribe or purchase for full access. References 1. Chitu, V. ∙ Gökhan, Ş. ∙ Stanley, E.R. Modeling CSF-1 receptor deficiency diseases - how close are we? FEBS Journal. 2022; 289:5049-5073 2. Guo, L. ∙ Bertola, D.R. ∙ Takanohashi, A. ...

To understand the transcriptional changes associated with the protective properties of microglia around plaques versus the white-matter neurodegeneration effects, we performed additional scRNA-seq profiling of the hippocampus and adjacent fimbria in TauPS2APP;Ptpn6-Wt, -het, and -cKO. 16 cell types were identified, and microglia, oligodendrocytes, and astrocytes were selected for further characterization based on strong genotype effects (Figures S8A and S8B).