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Jeanne E. Barthold on Muck Rack

Jeanne E. Barthold

As seen in: Cell Press
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Articles

Dedifferentiation alters chondrocyte nuclear mechanics during in vitro culture and expansion

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By Adrienne K. Scott, Benjamin Seelbinder, Jeanne E. Barthold
| Cell Press Verified
Abstract The biophysical features of a cell can provide global insights into diverse molecular changes, especially in processes like the dedifferentiation of chondrocytes. Key biophysical markers of chondrocyte dedifferentiation include flattened cellular morphology and increased stress-fiber formation. During cartilage regeneration procedures, dedifferentiation of chondrocytes during in vitro expansion presents a critical limitation to the successful repair of cartilage tissue.
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